美国希望之城博士后职位—淋巴细胞恶性肿瘤

美国希望之城博士后职位—淋巴细胞恶性肿瘤

希望之城国家医疗中心(City of Hope NationalMedical Center)是一所顶尖的美国非盈利研究和治疗中心，专注于癌症、糖尿病和其他危及生命的疾病。

Postdoctoral Fellow - Lymphoid Malignancies

City of Hope

Job Description

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

We are seeking a talented and motivated Postdoctoral Fellow to work in the laboratory of Dr. Srividya Swaminathan in the Department of Systems Biology at City of Hope. We study processes within lymphocytes and those outside (in the immune microenvironment) that drive the development of lymphoid malignancies including B- and T- cell acute lymphoblastic leukemia (ALL) and lymphomas. We apply this to develop therapies that specifically target malignant lymphocytes. Research in our lab spans Hematology, Oncology, and Immuno-Oncology. The Postdoctoral Fellow who joins the team will lead a project focused on specifically targeting diseased immune subsets in systemic lupus erythematosus (SLE) and indolent lymphomas. The Fellow will perform experiments using transgenic and transplantation mouse models of lymphoproliferative diseases, primary cells from patients, humanized mice, gene editing, classical molecular, cell biology, and biochemistry, and single cell sequencing approaches. The Fellow willalso contribute to other ongoing immuno-oncology projects in the team.

As a successful candidate, you will use the following methods:

·         Immune profiling (cytometry, scRNAseq).

·         In vivo assays (mouse genetics, intravenous and intrafemoral transplantation assays, subcutaneous pump implantation for delivery of candidate therapies, humanized mouse models, pre-clinical testing of immunotherapies in xenotransplantation models, bioluminescence imaging).

·         Molecular biology and biochemistry (retroviral/lentiviral transduction, molecular cloning, high throughput RNA/DNA sequencing, qPCR, immunoblotting, immunofluorescence, Luminex, CRISPR-based gene editing of immune cells).

Your qualifications should include:

·         PhD in Immunology, Cell, Molecular biology, or another field related to Life Sciences. Experience with flow cytometry.

·         Experience performing in vivo procedures in mice.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.

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Salary / Pay Rate Information:

Pay Rate: $31.00 - $34.23 / hour

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

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