美国H. Lee Moffitt癌症中心和研究所免疫肿瘤学和免疫疗法博士后职位

美国H. Lee Moffitt癌症中心和研究所免疫肿瘤学和免疫疗法博士后职位

The laboratory of Dr. Dennis Adeegbe at the Moffitt Cancer Center Department of Immunology in Tampa, Florida seeks to recruit a Postdoctoral Fellow to contribute to immuno-oncology research efforts.

The main focus of the lab is to understand the immunological and molecular landscape of solid tumor microenvironment with the goal of manipulating the immune component to promote anti-tumor immunity. In this regard, syngeneic, orthotopic and genetically engineered mouse models as well as patient specimen are employed in both basic and translational studies of melanoma, lung, and prostate cancers. The lab utilizes an array of cellular, molecular, biochemical, and genomic analytical techniques to interrogate pertinent questions in a number of in vitro and in vivo studies.

Position Highlights:

•Conduct independent and collaborative studies in an Immunology lab focusing on both basic and clinically-relevant translational studies.

•Opportunity to be a part of a fast-paced lab and acquire additional experience in Immuno-Oncology by contributing to projects and studies related to understanding the cancer immune environment.

•Be involved in exciting projects to understand Treg immunobiology in solid cancers and studies exploring novel immunotherapeutic strategies.

•Participation at scientific meetings, membership in relevant scientific organizations, and applying for training grants will be encouraged and supported.

Ideal Candidate:

•Will have solid experience working with lab animals and expertise in at least one of the following cellular biology techniques: •Multi-parameter flow cytometry; sample staining and acquisition, knowledge of analytical software such as Flowjo is a plus.

•Mouse and human cell culture; both primary cells as well as cell lines.

•Elispot or Luminex-based assays for cytokine/chemokine assessments.

•Immunofluorescent staining, imaging and fluorescent microscopy.

•Strong experience in cell signaling and molecular biology techniques: •Western blot, Co-IP

•Gene editing via shRNA/siRNA or CRISPR.

•Familiarity with murine syngeneic and genetically engineered models of lung/skin cancers as well as allografts/xenografts is a plus.

•Familiarity with genomic or epigenomic analytical platforms such as RNA-sequencing, ChIP-sequencing also a plus.

Responsibilities:

•Perform investigational studies utilizing animal models and patient specimen to understand the tumor microenvironment.

•Execute experiments independently and contribute to collaborative projects. Write manuscripts for publishing.

•Train and supervise junior staff and participate in overall lab management.

•Analyze and present data at local and national meetings.

Credentials and Qualifications:

Ph.D. and/or M.D. in Immunology, Cellular/Molecular Biology, or related fields with proven track record of productivity in form of publication in reputable journals. Hands-on-experience in laboratory research and good computer skills are required.

You will be eligible for benefits offered to our Team Members – Medical, Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. With a move to Tampa, you may be eligible for relocation allowance. Reason to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city with unique cultural attractions, low cost of living and a high quality of life. We strive for work/life balance.

If you have the vision, passion, and dedication to contribute to our mission,

then we have a place for you.

Interested applicants should apply to Req. 33274_Postdoc Fellow in Cancer Immunology and Immunotherapy and include a single PDF file of their current CV with publications list, and contact information for three references. For further inquiries, please email Dennis.Adeegbe@moffitt.org.