墨菲特癌症中心和研究机构药物研发博士后招聘

　　招聘简介：

　　·莫菲特癌症中心和研究所

　　·地点：佛罗里达州坦帕市

　　职位描述

　　Derek Duckett博士正在寻求在H. Lee Moffitt癌症中心的药物发现部聘请一位积极主动且独立的博士后研究员。鼓励申请人对药物发现项目感兴趣，以了解和开发增强癌症免疫检查点抑制剂的药剂。

　　该实验室的主要重点是确定新的抗癌靶点，开发这些靶标的新选择性分子探针作为询问其改变的信号传导如何驱动肿瘤进展，转移和治疗抗性的工具。使用制药实践，我们的目标是优化这些新探针作为潜在的治疗方法。成功的候选人将参与一个令人兴奋的新项目，以确定如何利用不同的细胞周期蛋白依赖性激酶信号调控来增强免疫检查点治疗的机制。

　　英文原文：

　　·         Moffitt Cancer Center and Research Institute

　　·         Location: Tampa, FL

　　Job Description

　　Dr. Derek Duckett is seeking to hire a highly motivated and independent postdoctoral fellow in the department of Drug Discovery at the H. Lee Moffitt Cancer Center. Applicants interested in a drug discovery project to understand and develop agents to enhance immune checkpoint inhibitors for cancer are encouraged to apply.

　　The main focus of the lab is identifying novel anti-cancer targets, developing, new selective molecular probes of these targets as tools to interrogate how their altered signaling drives tumor progression, metastasis and therapy resistance. Using pharmaceutical practices, we aim to optimize these new probes as potential therapeutics. The successful candidate will be involved in an exciting new project to determine the mechanism of how aberent regulation of cyclin dependent kinase signaling may be exploited to enhance immune checkpoint itherapies.

　　Position Highlights:

　　• The position is for a Postdoctoral fellow to join an interdisciplinary team to interrogate signal transduction pathways relating to altered transcription, immune checkpoints and cancer.

　　• Opportunity to gain drug discovery experience by contributing to projects and studies understanding the cancer immune microenvironment.

　　The Ideal Candidate:

　　• Successful cancdidates will have a strong background in cancer immunology with a keen interest in drug discovery research.

　　• Prior experience is required with some of the following techniques:

　　o mammalian cell culture,

　　o isolation of immune cell populations

　　o multi parameter flow cytometery , sample preparation and data aqcquistion.

　　o biochemistry/ enzymology,

　　o drug discovery cell-based assay development ,

　　o molecular and cell biology

　　o experience in vivo mouse efficacy and DMPK studies.

　　• Candidates with prior experience in cancer immunology will be given preference.

　　While experience in the above skills is highly preferred, applicants with related skills set are encouraged to apply.

　　Responsibilities:

　　• This individual will perform investigational studies using human cell lines, primary patient derived cells and tumor samples.

　　• Desigin and perform experiments independently and analyze data.

　　• Identify and validate targets from existing RNA seq and proteomic data sets.

　　• Perform experiments aimed at elucidating existing compound mechanism of action

　　• Participate in data interpretation and crafting manuscripts for publication

　　Credentials and Qualifications:

　　• MD or PhD in Immunology, Molecular Biology, Biochemistry, or relevant field with proven track record of productivity in form of publications..

　　Moffitt is the only Florida cancer center to receive the National Cancer Institute designation for its scientific excellence and offers unique opportunities for interdisciplinary collaborations at the forefront of finding new cancer cures.

　　How to Apply: Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Derek Duckett at derek.duckett@moffitt.org