美国华盛顿大学生理学、细胞生物学、生物化学或相关领域博士后招聘

　　招聘简介:

　　华盛顿大学医学院内分泌、代谢和脂质研究部的Irfan Lodhi博士的实验室有一个博士后职位。Lodhi实验室使用尖端技术，如Crispr/CAS9、下一代测序、脂质组学和蛋白质组学。实验室的总体目标是了解脂质代谢途径在调节能量平衡中的作用。我们特别感兴趣的是多功能的细胞器称为过氧化物酶体如何将脂质输送到离散的亚细胞间室，从而影响新陈代谢。在这一研究中，我们最近的研究表明过氧化物酶体衍生的脂质调节线粒体动力学和棕色脂肪介导的热生成（参见Park等人2019，临床研究杂志129（2）：694-711）。有关更多信息和完整的出版物列表，请访问我们的实验室网站（www.lodilab.org）。

　　申请人必须拥有生理学、细胞生物学、生物化学或相关领域的博士学位，并具有丰富的分子生物学经验，这一点在知名期刊上有明显的体现。有鼠标操作和手术经验是可取的，但不是必需的。有学习这些技巧的意愿者优先。在独立的分析思维，实验设计，故障排除，以及与实验室工作人员和调查人员有效沟通的能力方面的技能是非常需要的。邀请合格的候选人与Irfan Lodhi博士（ilodhi@wustl.edu）联系，并提供简历和三名推荐人的姓名。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Irfan Lodhi in the Division of Endocrinology, Metabolism & Lipid Research at Washington University School of Medicine. The Lodhi lab uses cutting-edge techniques such as CRISPR/Cas9, next-generation sequencing, lipidomics and proteomics. The overall goal of the lab is to understand the role of lipid metabolism pathways in the regulation of energy homeostasis. We are particularly interested in how the multifunctional organelles called peroxisomes channel lipids to discrete subcellular compartments to influence metabolism. In this line of investigation, our recent studies suggest that peroxisome-derived lipids regulate mitochondrial dynamics and brown fat-mediated thermogenesis (see Park et al. 2019, Journal of Clinical Investigation 129(2):694-711). For more information and a complete list of publications, please visit our lab website (www.LodhiLab.org).

　　The candidate must have a PhD in physiology, cell biology, biochemistry or a related field with strong experience in molecular biology evident by publication in reputable journals. Experience in mouse handling and surgery is desirable, but not required. Willingness to learn these techniques is preferred. Skills in independent analytical thinking, experimental design, troubleshooting, and the ability to effectively communicate with the laboratory staff and investigators are highly desired. Qualified candidates are invited to contact Dr. Irfan Lodhi (ilodhi@wustl.edu) with CV and names of three references.