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比利时布鲁塞尔ULB - Université Libre de Bruxelles博士后职位
文章来源:知识人网整理       更新时间:2019年03月25日

  招聘简介:

  描述

  在比利时布鲁塞尔Iribhm由Benjamin Beck领导的“食管癌和化生特征”实验室(https://www.benjamin beck lab.com)有一个获得资助的两年博士后职位(https://iribhm.org)。我们的实验室有兴趣通过多种技术和几种转基因小鼠模型来描述化生的发展及其向癌症发展的机制。

  项目大纲

  食管柱状化生是腺癌的主要危险因素之一。我们的目的是了解食管细胞是如何经历一个转分化过程来产生化生的,以及后者是如何发展成腺癌的。为此,我们将使用基于转基因小鼠模型、器官培养、条件敲除和过度表达系统、facs分类细胞的表观遗传和转录测序以及crispr/cas9基因编辑的多学科方法。我们建议挑战肥胖、慢性炎症和致癌作用对柱状化生向肠道化生和癌症进展的影响。

  英文原文:

  Description

  A funded two-year postdoctoral position is available in the “Characterization of Esophageal Cancers and Metaplasia” lab (https://www.benjaminbecklab.com) headed by Benjamin Beck at the IRIBHM, Brussels, Belgium (https://iribhm.org). Our lab is interested in characterizing the mechanisms involved in the development of metaplasia and their progression into cancer by using a variety of techniques and several transgenic mouse models.

  Project Outline

  Columnar metaplasia of the esophagus constitutes one of the main risk factors for adenocarcinoma. We aim at understanding how esophageal cells undergo a process of transdifferentiation to generate metaplasia and how the latter then progress into adenocarcinoma. To this end, we will use a multidisciplinary approach based on transgenic mouse models, organoid culture, conditional knockout and overexpression systems, epigenetic and transcriptomic sequencing of FACS sorted cells as well as CRISPR/Cas9 gene editing. We propose to challenge the impact of obesity, chronic inflammation and oncogenic hits on the progression of columnar metaplasia towards intestinal metaplasia and cancer.

  Profile

  The applicants of any nationality must hold a PhD and/or a MD degree (for less than 7 years) and should be highly motivated. The applicants should have a strong background in cancer biology. Technical expertise in handling transgenic mouse models, organoids and/or CRISPR/Cas9 gene editing will be of advantage. Excellent communication skills are expected.

  How to apply?

  Interested candidates are encouraged to submit a motivation letter describing their background, a CV and two references letters to Benjamin Beck (benjamin.beck@ulb.ac.be).

  Please visit our website for more information: https://www.benjaminbecklab.com.

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