比利时VIB-KU Leuven Center生物医学科学、神经生物学、生物物理学、生物信息学或相关领域博士后招聘

　　招聘简介：

　　由Thomas Voets领导的离子通道研究实验室（LICR）是一个充满活力的国际研究团队，位于Vib-Ku-Leuven脑与疾病研究中心（Vib-CBD）和Ku-Leuven细胞与分子医学部。

　　LICR的研究主要集中在瞬时受体电位（TRP）离子通道，我们使用多种分子、细胞和体内方法来研究其功能特性、细胞调节和（病理）生理作用。此外，通过与临床和工业合作伙伴的密切合作，我们旨在将这些知识转化为新的基于TRP通道的治疗方法，以治疗慢性疼痛、糖尿病、心脏病和膀胱功能障碍等重要疾病。

　　职位描述

　　我们目前正在寻找一位才华横溢、积极进取的博士后研究员加入我们的团队，研究TRP和相关离子通道在躯体感觉和疼痛中的作用。

　　总的目标是阐明确定皮肤和其他靶器官中感觉通道的定位和功能的细胞和亚细胞过程，明确这些过程在病理性疼痛状态下的影响，并利用这些知识设计慢性疼痛的新治疗策略。在这一研究背景下，成功的候选人将有很大的自由去发展自己的研究问题和项目。

　　英文原文:

　　About the Lab

　　The Laboratory of Ion Channel Research (LICR), headed by Thomas Voets, is a vibrant and international research team, embedded in the VIB-KU Leuven Center for Brain and Disease Research (VIB-CBD) and the KU Leuven Department of Cellular and Molecular Medicine.

　　Research within LICR is focused on transient receptor potential (TRP) ion channels, and we use a large variety of molecular, cellular and in vivo approaches to study their functional properties, cellular regulation and (patho)physiological roles. Moreover, through intense collaborations with clinical and industrial partners, we aim at translating this knowledge into new TRP channel-based therapies for important medical conditions including chronic pain, diabetes, cardiac disease and bladder dysfunction.

　　Job description

　　We are currently looking for a talented and motivated postdoctoral researcher to join our team investigating the role of TRP and related ion channels in somatosensation and pain.

　　The overall objective is to elucidate cellular and subcellular processes that determine the localization and function of sensory channels in the skin and other target organs, to define how these processes are affected in pathological pain states, and to use this knowledge to design novel treatment strategies for chronic pain. Within this research context, the successful candidate will have a large degree of freedom to develop her/his research question and project.

　　Profile

　　Essential:

　　A PhD in biomedical sciences, (neuro)biology, biophysics, bioinformatics or related field

　　Effective written and verbal English communication skills

　　A strong publication record with first-author papers in well-established international journals

　　Desirable but not required:

　　Hands-on experience with the following is an asset: super-resolution imaging, single-cell transcriptomics, in vivo imaging, patch-clamp electrophysiology, pain models, bioinformatics

　　We offer

　　An internationally renowned research team (LICR), within a top quality neuroscience center (VIB-CBD), located in Europe’s most innovative university (KU Leuven)

　　Direct access to state-of-the-art infrastructure and core facilities at VIB-CBD and KU Leuven

　　Excellent personal development opportunities in both scientific and academic career skills

　　Financial support is available for 3 years but the successful candidate is encouraged to obtain an independent fellowship (Marie-Curie, EMBO, or National funding organizations) during this time.

　　How to apply?

　　Please complete the online application, including the following items:

　　Your CV with publication list

　　The names and email addresses of 2 referees

　　A one-page letter outlining your motivation and research vision

　　For more information please contact Thomas Voets.

　　For extra information:

　　https://gbiomed.kuleuven.be/LICR

　　https://cbd.vib.be/careers/

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　　Have a look at some of our recent publications:

　　• Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T: A TRP channel trio mediates acute noxious heat sensing. Nature 2018, 555:662-666.

　　• Janssens A, Gees M, Toth BI, Ghosh D, Mulier M, Vennekens R, Vriens J, Talavera K, Voets T: Definition of two agonist types at the mammalian cold-activated channel TRPM8. Elife 2016, 5.

　　• Ghosh D, Pinto S, Danglot L, Vandewauw I, Segal A, Van Ranst N, Benoit M, Janssens A, Vennekens R, Vanden Berghe P, Galli T, Vriens J, Voets T: VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nature Communications 2016, 7:10489.

　　• Uvin P, Franken J, Pinto S, Rietjens R, Grammet L, Deruyver Y, Alpizar YA, Talavera K, Vennekens R, Everaerts W, De Ridder D, Voets T: Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency. European Urology 2015, 68:655-661.

　　•  Vriens J, Nilius B, Voets T: Peripheral thermosensation in mammals. Nature Reviews Neuroscience 2014, 15:573