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美国新泽西罗格斯新泽西癌症研究所博士后职位
文章来源:知识人网整理       更新时间:2019年03月04日

  招聘简介:

  我们正在寻找一位积极性很高的博士后研究员,加入新泽西州罗格斯癌症研究所儿科血液学/肿瘤科和罗伯特伍德约翰逊医学院的Advaitha Madireddy博士(www.madireddylab.com)实验室。我们实验室的研究重点是研究新的分子机制和致癌途径,这些途径是癌症易感性综合征和血液系统恶性肿瘤的发病机制的基础。特别是,我们正在研究缺陷复制,转录和修复对Fanconi贫血(FA)(Madireddy等,2017; Madireddy等,2016)和成人T细胞白血病/淋巴瘤等疾病中基因组不稳定性的贡献。除了我们关于确定癌症易感性的分子基础的研究之外,我们还有兴趣了解使用人类干细胞模型进行FA的造血干细胞衰竭/磨损和骨髓衰竭的主要机制。其他广泛的研究重点包括:脆性基因组热点的非B DNA,解旋酶/跨转录聚合酶/核酸酶和转录:复制冲突。

  我们的团队已纳入我们NCI指定的癌症研究所的基因组不稳定性和癌症遗传学计划。这个机会非常适合对基础癌症研究感兴趣的博士后。

  英文原文:

  We are seeking a highly motivated postdoctoral fellow to join the laboratory of Dr. Advaitha Madireddy (www.madireddylab.com) in the Division of Pediatric Hematology/Oncology at the Rutgers Cancer Institute of New Jersey and the Robert Wood Johnson Medical School. The research in our laboratory focuses on investigating novel molecular mechanisms and oncogenic pathways that underlie the pathogenesis of cancer-predisposition syndromes and hematological malignancies. In particular, we are exploring the contribution of defective replication, transcription and repair to genomic instability in disorders like Fanconi anemia (FA) (Madireddy et al., 2017; Madireddy et al., 2016) and Adult T-cell leukemia/lymphoma. In addition to our studies on determining the molecular basis of cancer-predisposition, we are also interested in understanding the primary mechanisms underlying hematopoietic stem cell exhaustion/attrition and bone marrow failure using a human stem cell model for FA. Additional broad areas of research emphasis include: Non-B DNA at genomic hotspots of fragility, helicases/translesion polymerases/nucleases, and transcription: replication conflicts.

  Our team is integrated into the Genomic Instabilities and Cancer Genetics Program at our NCI-designated Cancer Institute. This opportunity is ideal for postdocs who are interested in basic cancer research.

  Qualifications:

  o PhD in molecular biology, cell Biology, biochemistry or related area. Recent PhD graduates and candidates with prior postdoctoral experience who are committed to a dynamic career in science are encouraged to apply.

  o Able to design research projects, perform hands on experiments, and maintain detailed documentation.

  o Highly motivated, creative, and devoted to project and career goals.

  o Able to collaborate proficiently and communicate effectively with colleagues.

  Experience:

  o A strong background in molecular, cell and(or) cancer biology is essential.

  o Hands-on experience with general molecular biology techniques and in vitro assays commonly used to study DNA replication, transcription, and DNA repair preferred.

  o Prior experience in at least one of the following techniques is strongly desired: Human stem cell culture (hematopoietic stem cell culture), ChIP-seq analysis, Crispr/Cas9 genome editing.

  To apply, please email a cover letter, CV, and the names and contact information (including phone numbers) of three references to Advaitha.madireddy@rutgers.edu. In addition, please submit an online application through the following website: https://jobs.rutgers.edu/postings/84525

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