美国芝加哥大学博士后职位

　　招聘简介：

　　激动人心的博士后培训机会，在芝加哥大学开发新型流感疫苗

　　我们正在寻找一名博士后研究员来开发和测试新的通用流感疫苗候选人。

　　这项比尔和梅琳达盖茨基金会资助的职位将涉及B淋巴细胞和抗体对流感的反应的研究，以开发新的通用流感疫苗候选人。针对流感的真正普遍的疫苗接种策略必须管理病毒的逃逸突变以及抗体对抗保护性和耐久性不同的表位的反应的演变。所提出的疫苗旨在通过选择针对具有免疫原性和保护作用的表位的抗体并远离具有免疫原性但不具有保护作用的表位，通过增强对流感上多个保守的保护性表位的响应来最小化病毒逃逸。我们将使用独特而强大的观察，实验和计算设计来开发这种候选疫苗。整个项目将涉及三个研究所的四个小组的协作努力，包括：芝加哥大学的Patrick Wilson和Sarah Cobey小组，西奈山伊坎医学院的Florian Krammer实验室和Jesse Bloom的实验室在弗雷德哈钦森癌症中心。

　　英文原文：

　　Exciting postdoctoral training opportunity developing novel influenza vaccines at the University of Chicago

　　We are seeking a Postdoctoral Fellow to develop and test novel universal influenza vaccine candidates.

　　This Bill and Melinda Gates Foundation-funded position will involve studies of B lymphocyte and antibody responses to influenza for development of novel universal influenza vaccine candidates. A truly universal vaccination strategy against influenza must manage escape mutations by the virus and the evolution of antibody responses to and away from epitopes that differ in their protectiveness and durability. The proposed vaccine aims to minimize viral escape by boosting responses to multiple conserved, protective epitopes on influenza by selecting for antibodies to epitopes that are immunogenic and protective, and away from epitopes that are immunogenic but not protective. We will develop this candidate vaccine using a unique and powerful set of observations, experiment, and computational design. The over-all project will involve the collaborative efforts of four groups at three institutes, including: the groups of Patrick Wilson and Sarah Cobey at the University of Chicago, Florian Krammer’s laboratory at the Icahn School of Medicine at Mount Sinai, and Jesse Bloom’s laboratory at the Fred Hutchinson Cancer Center.

　　The position with will involve use of technologies such as flow cytometry, single-cell transcriptomics (i.e., 10x Genomics technology), plus generation and characterization of human monoclonal antibodies and ultimately production and testing of novel influenza vaccine candidates.

　　Candidates should have completed a doctorate level degree and have a strong background in vaccinology and/or immunology, preferably related to B cells and antibodies. The successful candidate should have documented success in research including publications in international journals on relevant topics. Compensation is dependent upon qualifications. The University provides a generous package of fringe benefits.

　　Applicants should submit an application package that includes a cover letter, CV, relevant prior publications, and contact information for three references to Patrick Wilson, at wilsonp@uchicago.edu.

　　Application review will begin immediately and continue until the position is filled.

　　Patrick C. Wilson. PhD

　　Professor of Medicine/ Section of Rheumatology

　　The Committee on Immunology

　　The University of Chicago