当前位置:知识人网 >> 国外博士后招聘 >> 正文内容

美国纽约西奈山伊坎医学院博士后职位
文章来源:知识人网整理       更新时间:2019年03月04日

  招聘简介:

  转录组学归因和精神病学基因组学

  在西奈山的Pamela Sklar智者基因组学部门的弱势群体实验室分析基因组学(“Huckins实验室”)中可以获得博士后职位。该职位将主要关注转录组学和多组学Imputation模型的开发和应用,以及应用于精神疾病GWAS。

  转录组学插补(TI)方法利用大型,精心策划的eQTL参考组,以预测基因型的基因表达。 TI模型可应用于任何大型基因型集合(即GWAS),以在病例和对照中获得预测的遗传调节的基因表达,从而鉴定基因表达与疾病之间的关联。这些更高级别的基因关联可以提供更大的可解释性。

  作为Huckins实验室的一部分,您将有助于扩展和改进这些方法,以合并新的精心设计的转录组,组蛋白修饰和微生物组数据集,以便从基因型构建多组学数据的预测因子。在我们的分析的每个阶段,我们将这些预测因子应用于精神分裂症,双相情感障碍和神经性厌食症GWAS数据,以揭示更多关于这些精神疾病的多原因风险。

  博士后候选人可能会建议将重点放在这些模型的开发上,包括,例如,提出新的统计方法,利用eQTL架构的知识,扩展模型以包括新的人口(等);或者将这些模型应用于精神病学GWAS数据,并对结果进行解释。

  英文原文:

  Transcriptomic Imputation & Psychiatric Genomics

  A postdoctoral positions is available in the Analytical Genomics of Vulnerable Populations Lab (“Huckins Lab”), in the Pamela Sklar Division of Psychiatric Genomics at Mount Sinai. The position will have a primary focus on the development and application of Transcriptomic and multi-omic Imputation models, and application to psychiatric disorder GWAS.

  Transcriptomic Imputation (TI) approaches leverage large, well-curated eQTL reference panels in order to predict gene expression from genotype. TI models can be applied to any large collection of genotypes (i.e., GWAS) to obtain predicted genetically regulated gene expression in cases and controls, and thereby identify associations between gene expression and disease. These higher-level genic associations may provide greater interpretability.

  As part of the Huckins Lab, you will help to extend and improve these methods to incorporate new well-curated transcriptome, histone modification, and microbiome datasets, in order to build predictors of multi-omic data from genotypes. At every stage of our analysis, we will apply these predictors to schizophrenia, bipolar disorder and anorexia nervosa GWAS data in order to reveal more about multi-omic risk for these psychiatric disorders.

  Postdoctoral candidates may propose to focus either on development of these models, including, for example, proposing novel statistical approaches, leveraging knowledge of eQTL architecture, extending models to include new populations (etc); or on the application of these models to psychiatric GWAS data, and interpretation of results.

  To achieve these goals, you will have access to world-class transcriptome, microbiome and genetic datasets. We collaborate closely with the CommonMind Consortium, Psychiatric Genomics Consortium, and PsycheMERGE consortium, and have access to >1,000 post-mortem brain samples, genotypes for >100,000 individuals with psychiatric disorders, and matched genotype and electronic health record data for >160,000 individuals.

  Your skills

  A successful candidate will be motivated and enthusiastic about understanding the neurobiology of psychiatric disorders, and will show a wide interest in the work of the psychiatric genomics division. Ideally, you will enjoy communicating and explaining your work to peers and students, and have experience writing clearly and succinctly.

  Essential Skills:

  • Ability to work collaboratively and as part of a team

  • Creativity and curiosity in developing new algorithms

  • A commitment to thorough, rigorous research, and a thoughtful approach to problem solving

  • Respect and compassion for patients and research participants.

  • Strong programming skills: working knowledge of R and UNIX will be essential.

  • A PhD in a relevant field- statistical/human/psychiatric genetics, or similar

  • Previous experience with genetic/transcriptomic data

  Ideal Skills:

  • Strong publication record

  • Ability to present work clearly and confidently

  • Knowledge of standard GWAS/TWAS software and pipelines

  Scientific Environment

  The Huckins Lab is part of the Pamela Sklar Division of Psychiatric Genomics, in the Icahn School of Medicine, New York. As a division, our focus is on understanding the causes, outcomes, and treatment of psychiatric disorders. Our researchers have diverse interests and backgrounds, including computational, wet-lab and clinical research teams, as well as post-doctoral fellows, grad students, and bioinformaticians. We hope that you will work collaboratively with this diverse groups of researchers, and will contribute to our goal of understanding psychiatric disease.

  The Icahn School of Medicine at Mount Sinai offers a range of support for postdoctoral fellows, including grant writing and resume workshops; generous internal funding opportunities; seminars and symposia on professional development; support and funding tailored specifically to under-represented groups in STEM; international personnel office to support immigration needs. Further information may be found here: http://icahn.mssm.edu/education/postdoc

  The Huckins Lab does not tolerate harassment of anybody, in any form. All members of the lab are required to abide by our code of conduct at all lab-related events. (https://github.com/laurahuckins/HuckinsLab/)

  Terms and Benefits

  The Icahn School of Medicine at Mount Sinai is situated on the Upper East Side of Manhattan, one block from Central Park. New York landmarks including the Metropolitan Museum of Art, the Guggenheim, and the Central Park Reservoir are a ~10 minute walk away. Our campus is surrounded by boutiques, restaurants, art and sculpture, as well as being a hub for scientific discourse and collaboration.

  The Icahn School of Medicine at Mount Sinai provides excellent benefits to postdoctoral fellows, including subsidized housing on the Upper East Side of Manhattan (http://icahn.mssm.edu/education/postdoc/housing). We also offer a range of discounts for Broadway shows, museum entry, movies and sports events, as well as subsidized gym and health club passes, and other benefits (http://recreation.mountsinaihealth.org/)

  We provide a range of benefits to parents and carers, including child care; on-site lactation rooms; parent’s social and support groups; financial support with child and dependent care. We will take family schedules and commitments into account when scheduling our lab activities and meetings.

  Salary will be commensurate with years of experience, and is set above NIH guidelines to counter NYC living expenses.

  How to apply

  To apply for this position, email a cover letter and up-to-date CV to laura.huckins @ mssm.edu

  Please include the names & contact details for two references in your application.

  We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity and expression, marital status, protected veteran status (if applicable) or any other characteristic protected by law.

扫一扫知识人网官方微信订阅号,关注更多学术资讯、博士后招聘信息。
国外博士后、访问学者申请免费专业评估,专业顾问在线答疑解惑。

快速申请国外博士后(免费评估)


点击这里快速申请国外博士后

点击这里快速申请国外访问学者

知识人网是专职国外博士后访问学者申请的服务机构,获评“北京诚信服务示范单位”。
自2004年起,累计十余年申请经验,以大量名校申请成功案例、及全球三万余所院校导师资源为基石,提供优质的申请咨询服务。
400电话:400-060-0581,欢迎您随时来电咨询!