冷泉港实验室造血系统恶性肿瘤博士后招聘

　　招聘简介：

　　张春波博士在冷泉港实验室的实验室正在寻找博士后研究员，为各种形式的破坏性造血系统恶性肿瘤开发新的治疗方法。张实验室有兴趣了解造血干细胞和祖细胞的自我更新如何在正常和恶性条件下受到调节，以及自我更新过程的失调如何促成各种造血系统恶性肿瘤的发病机制。该实验室正在通过CRISPR / Cas功能和化学基因组方法解决这些问题，以识别新的自我更新调节剂和代谢脆弱性，并最终开发化学探针以将这些分子事件作为造血系统恶性肿瘤的新疗法。

　　英文原文：

　　Dr. Lingbo Zhang’s Lab at Cold Spring Harbor Laboratory is seeking postdoctoral fellow to develop novel therapeutics for various forms of devastating hematopoietic malignancy. The Zhang Lab is interested in understanding how self-renewal of hematopoietic stem and progenitor cell is regulated under both normal and malignant conditions and how dysregulation of self-renewal process contributes to pathogenesis of various hematopoietic malignancies. The Lab is addressing these questions through both CRISPR/Cas functional and chemical genomic approaches to identify novel self-renewal regulators and metabolic vulnerabilities and to ultimately develop chemical probes to target these molecular events as novel therapeutics for hematopoietic malignancies.

　　The Lab has recently identified multiple promising drug targets to treat hematopoietic malignancies including myelodysplastic syndrome and acute leukemia. A clinical trial based on one of these drug targets to treat drug-refractory myelodysplastic syndrome is currently under preparation. The Lab is now seeking outstanding candidate to functionally characterize drug targets and identify molecular markers that predict responsiveness to these novel therapeutics. The ultimate goal is to develop novel therapeutics for various forms of devastating hematopoietic malignancy.

　　Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program.

　　Position Requirements:

　　Candidates should hold a graduate degree (PhD, MD or equivalent) in biomedical fields. Interested candidates should send cover letter, CV, research statement (including research accomplished during PhD and research expected to work on during postdoctoral fellowship), and 3 contacts for reference to lbzhang@cshl.eduas well as online application found here: http://cshl.peopleadmin.com/postings/14939

　　Cold Spring Harbor Laboratory offers a highly collaborative social and scientific environment as well as a competitive salary and benefits in a beautiful location about one hour from New York City.

　　Position Number: 02318-R

　　CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.