美国布朗大学机械应力方向博士后职位招聘

　　招聘简介：

　　博士后职位 - 心脏发育和再生中的机械转导

　　布朗阿尔珀特医学院（AMS），布朗大学

　　博士后职位 -

　　心脏发育和再生中的机械转导

　　我们正在寻找一位具有创造性和特殊动机的候选人，以填补心脏发育和再生领域的博士后职位。 Radice实验室的研究旨在揭示心肌细胞如何感知和响应机械力的分子，生化和细胞基础。我们目前的研究重点是鉴定N-钙粘蛋白如何与潜在的细胞骨架一起将力传递到细胞中并激活控制肌细胞增殖的信号事件（Li等，Circ.Res.2015; Vite等，Development 2018）。该职位提供了一个令人兴奋的机会，在高度协作，友好和激励的环境中，在基础研究和转化研究的界面上工作，并在发展和再生生物学的最前沿获得各种技术方法的经验。

　　英文原文：

　　Postdoctoral Position – Mechanotransduction in Heart Development and Regeneration

　　Brown Alpert Medical School (AMS), Brown University

　　Postdoctoral Position –

　　Mechanotransduction in Heart Development and Regeneration

　　We are seeking a creative and exceptionally motivated candidate to fill a post-doctoral position in the field of cardiac development and regeneration. Research in the Radice lab is directed at uncovering the molecular, biochemical and cellular basis for how heart muscle cells sense and respond to mechanical force.  Our current research emphasis is to identify how N-cadherin together with the underlying cytoskeleton transmits force into the cell and activates signaling events that control myocyte proliferation (Li et al., Circ. Res. 2015; Vite et al., Development 2018).  The position provides an exciting opportunity to work at the interface of basic and translational research in a highly collaborative, friendly and stimulating environment, and gain experience in a diverse set of technical approaches at the cutting edge of developmental and regenerative biology.

　　Candidates should hold a Ph.D. and/or M.D. with research training in the fields of cellular and molecular biology. The project utilizes genetically altered mouse models and primary cell culture. Experience in cardiomyocyte isolation and neonatal cardiomyocyte culture is highly preferred. Background in mechanobiology is desirable. Qualified candidates should possess strong communication and interpersonal skills, attention to detail, self-motivation, and the ability to work independently. This position provides an excellent opportunity to grow scientifically and work with a dynamic group of investigators studying important and exciting aspects of cardiac biology (http://cvrc.brownmedicine.org). Brown offers a world-class research environment, very attractive benefits, and an appealing location in historic Providence, RI.

　　Interested applicants should send a singlePDFfile including:

　　1) Cover letter (please state how you heard about the position)

　　2) CV demonstrating publication of impactful work

　　3) One-page statement of research interests

　　4) Contact information for three references

　　Please email your application to Glenn Radice (gradice@lifespan.org) using the subject heading “Postdoctoral Fellow position”.