挪威奥斯陆大学细胞免疫学方向博士后职位招聘

　　招聘简介：

　　细胞生物学/细胞免疫学博士后研究奖学金

　　奥斯陆大学（UiO）

　　职位描述

　　奥斯陆大学数学与自然科学学院生物科学系的Cinzia Progida副教授和Oddmund Bakke教授的研究小组提供了两个博士后研究员职位。

　　这些职位的候选人将参与挪威研究理事会资助的一个项目，题为：“细胞 - 细胞骨架串扰，用于免疫的细胞内协调”。这是挪威团队与Leiden的Jacques Neefjes教授和新加坡的Michael Sheetz教授之间的合作项目。该项目的目标是确定协调细胞骨架动力学和细胞内膜转运之间相互作用的分子和途径，并进一步表征这种相互作用如何调节抗原内化，转运和呈递以及树突细胞中的细胞迁移。该项目将利用蛋白质组学和生物信息学来确定该法规所涉及的相互作用网络。该项目还依赖于先进成像技术的使用，如活细胞成像/超分辨率结合生物物理分析，以研究尺寸提示和底物硬度对抗原识别后细胞内转运和细胞骨架动力学的影响。

　　英文原文：

　　Postdoctoral Research Fellowships in Cell Biology/Cellular Immunology

　　University of Oslo (UiO)

　　Job description

　　Two positions as postdoctoral research fellow are available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo in the research groups of Associate Professor Cinzia Progida and Professor Oddmund Bakke.

　　The candidates for these positions will work on a project funded by the Norwegian Research Council entitled: ”Membrane-cytoskeleton crosstalk for the intracellular coordination of immunity”. This is a collaborative project between the Norwegian groups and Prof. Jacques Neefjes in Leiden and Prof. Michael Sheetz in Singapore. The goal of this project is to identify molecules and pathways that coordinate the interplay between cytoskeleton dynamics and intracellular membrane transport, and to further characterize how this interplay regulates antigen internalization, transport and presentation as well as cell migration in dendritic cells. The project will make use of proteomics and bioinformatics to identify the network of interactions involved in this regulation. The project also depend on the use of advanced imaging techniques such as live cell imaging/super-resolution combined with biophysical assays to study the effect of dimensional cues and substrate stiffness on intracellular transport and cytoskeletal dynamics upon antigen recognition.

　　The laboratory of Assoc. Prof. Cinzia Progida is closely linked to the Eurobioimaging Advanced imaging node NorMIC Oslo, headed by Prof. Oddmund Bakke with access to a wide range of the latest imaging equipment and methods. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services.