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美国马里兰大学医学院分子和细胞生物学,癌症生物学方向博士后招聘
文章来源:知识人网整理       更新时间:2019年02月26日

  招聘简介:

  癌症代谢实验室的博士后职位

  在马里兰大学医学院的Marlene和Stewart Greenebaum综合癌症中心立即获得博士后职位,以研究白血病代谢(用天冬酰胺酶联合疗法靶向细胞中的谷氨酰胺代谢及其微环境)。此外,该实验室将重点通过代谢途径成瘾克服对FLT3抑制剂,Bcl-2和Mcl-1在急性髓细胞白血病(AML)中的抑制作用,并研究抗CD19免疫治疗的耐药机制以及评估其机制。通过蛋白质的唾液酸酶/唾液酸化状态对抗CD22(Siglec-2)和抗CD33(Siglec-3)的抗性。博士后研究员将有机会在这个NCI指定的综合癌症中心,在良好的指导环境中研究白血病患者和小鼠AML模型的原代细胞。

  英文原文:

  Postdoctoral Position in Cancer Metabolism Laboratory

  A postdoctoral position is immediately available in the Marlene and Stewart Greenebaum Comprehensive Cancer Center at University of Maryland School of Medicine to study leukemia metabolism (targeting glutamine metabolism in cells and their microenvironment with asparaginase combination therapy).  In addition, the lab will focus on overcoming resistance to FLT3 inhibitors, Bcl-2 & Mcl-1 inhibition in acute myeloid leukemia (AML) via metabolic pathways addiction, and investigating mechanism of resistance to anti-CD19 immunotherapeutics as well as evaluating mechanism of resistance to anti-CD22 (Siglec-2), and anti-CD33 (Siglec-3) via sialidase/sialylation status of the proteins. The postdoctoral fellow will have the opportunity to study primary cells from leukemia patients and mouse AML models in a well-mentored environment at this NCI-designated comprehensive cancer center.

  Requirements:  Highly motivated PhD or MD/PhD students who graduated within four years are encouraged to apply. A solid background and working experience in the following areas are highly desired:

  1.  Molecular and

  Cellular Biology, Cancer Biology

  2.  Metabolic Pathways

  3.  Hematologic Pathways

  Preferred candidates should be fluent in English.  Please e-mail an application including a cover letter describing current research, future interests, expected start date, and CV, selected publications, names and contact information of three references to:

  Ashkan Emadi, MD, PhD

  Professor of Medicine and Pharmacology

  University of Maryland School of Medicine

  Associate Director for Clinical Research

  Marlene and Stewart Greenebaum Comprehensive Cancer Center

  Email: aemadi@umm.edu

  The University of Maryland, Baltimore is an

  Equal Opportunity/Affirmative Action Employer.  Minorities, women,

  individuals with disabilities, and protected veterans are encouraged to apply.

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