德国亥姆霍兹环境保健中心胚胎学博士后职位

　　职位描述：

　　NeuherbergbeiMünchen，巴伐利亚，德国

　　工作组：

　　功能表观遗传学研究所

　　研究领域：

　　科学/博士后职位

　　开始日期：

　　2019年4月1日

　　合同期限：

　　2021年3月31日

　　职位描述：

　　作为德国环境健康研究中心，HelmholtzZentrumMünchen致力于开发个性化医疗方法，以预防和治疗糖尿病，过敏症和肺病等主要常见疾病。为此，它研究了遗传，环境因素和生活方式的相互作用。

　　慕尼黑亥姆霍兹中心的功能表观遗传学研究所（IFE）专注于了解表观遗传机制如何调节细胞的身份和功能。具体而言，我们想要揭示染色质修饰如何通过基因表达的变化来调节这些过程。我们的研究包括下一代测序（ChIPseq，RNAseq，CLIP等），单细胞方法，生物化学以及各种发育和细胞生物学系统。

　　对于我们的研究团队，我们目前正在寻找一个

　　表观遗传学中的PostDoc（f / m / d）

　　2019/0047

　　职位描述

　　对于染色质生物化学，表观遗传学和表型遗传学的间期项目，我们正在寻找具有强大研究背景，表观遗传学或染色质领域经验以及经过验证的出版记录的PostDoc。成功的候选人将研究新的染色质修饰途径，包括我们最近发现的DNA和RNA修饰，以解决表观遗传学中的一个核心问题：细胞环境控制基因表达程序和疾病状态（如癌症）的机制是什么？

　　该项目将涉及体外和体内方法的结合，包括不同的NGS（组学）技术及其分析，以及开发新的创新技术，以解决单细胞和低输入材料的机制。它旨在使申请人在确定其方向方面发挥重要作用，同时受益于激烈的国际合作以及其他研究所成员的深刻的表观遗传学和染色质背景。

　　你的资格

　　这个职位的候选人应该：

　　生物学或相关领域的博士生染色质研究的强大研究背景，具有非常好的出版记录至少有以下两个领域的经验是必不可少的：染色质生物化学ChIP seq和RNA seq技术（包括数据分析）单细胞方法流利的英语需要德语知识不需要

　　我们的意向

　　在HelmholtzZentrumMünchen，您可以与领先的研究人员共同研究糖尿病，慢性肺病和过敏等环境疾病的发展，预防和治疗。为了进一步促进您的专业发展，我们提供广泛和有针对性的研究培训和职业计划。我们通过灵活的工作时间模型，职业健康管理，儿童日托设施，儿童保育补贴，老年护理以及其他咨询和支持服务，支持工作与私人生活之间的和解。

　　薪酬和福利符合公共服务集体协议（TV EntgO Bund）。该职位（最初）限于2年。

　　作为全面质量奖的持有者，我们促进机会均等。为了增加女性担任管理职位的比例，我们很乐意收到相应的申请。合格的身体残疾申请人将被优先考虑。

　　我们期待收到您的综合在线申请，直到2019年3月31日。

　　英文原文：

　　Neuherberg bei München, Bavaria, Germany

　　Work group:

　　Institute of Functional Epigenetics

　　Area of research:

　　Scientific / postdoctoral posts

　　Starting date:

　　01.04.2019

　　Contract time limit:

　　31.03.2021

　　Job description:

　　As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

　　The Institute of Functional Epigenetics (IFE) at the Helmholtz Center Munich focuses on understanding how epigenetic mechanims regulates cellular identity and function. Specifically we want to unravel how chromatin modifications regulate these processes through changes in gene expression. Our research includes next generation sequencing (ChIPseq, RNAseq, CLIP etc.), single cell approaches, biochemistry as well as various developmental and cell biology systems.

　　For our research team we are currently looking for a

　　PostDoc in Epigenetics (f/m/d)

　　2019/0047

　　Job Description

　　For a project on the interphase between chromatin biochemistry, epigenetics and epitranscriptomics we are looking for a PostDoc with a strong research background, experience in the epigenetics or chromatin field and a proven publication record. The successful candidate will study novel chromatin modifying pathways including DNA and RNA modifications, which we have recently identified, to address a central question in epigenetics: what are the mechanisms via which the cellular environment controls gene expression programs and disease states, such as cancer?

　　This project will involve a combination of in vitro and in vivo approaches, including different NGS (omics) techniques and their analysis as well the development of novel innovative technologies to address mechanism in single cells and low-input material. It is designed to allow the applicant to play a major role in determining its direction and at the same time benefit from intense international collaborations as well as the profound epigenetics and chromatin background of the other Institute members.

　　Your Qualification

　　Candidates for this position should have:

　　PhD in biology or a related field Strong research background in chromatin research with a very good publication recordExperience in at least two of the following fields is essential:Chromatin biochemistryChIP seq and RNA seq techniques (including data analysis)Single cell approachesFluent English is requiredknowledge of German is not required

　　Our Offer

　　At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

　　Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund). The position is (initially) limited to 2 years.

　　As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

　　We are looking forward to receiving your comprehensive online application until March 31st 2019.