当前位置:知识人网 >> 国外博士后招聘 >> 正文内容

美国约翰霍普金斯大学遗传学/生物统计学方向博士后招聘
文章来源:知识人网整理       更新时间:2018年12月11日

  Postdoctoral position is available at the Andrew Feinberg lab for study of the epigenetics of cancer, metabolism, and behavior, focused on disease mechanisms, model organisms, and the role of epigenetics in gene-environment interaction. All of the studies are interdisciplinary, involving collaborating faculty in experimental design and mentorship at the Johns Hopkins University School of Medicine, preparing fellows for team-based jobs grounded in outstanding scholarship. We are addressing the following scientific questions:

  What are the epigenetic drivers of cancer progression? We are determining how mutations in epigenetic modifier genes alter the epigenetic landscape in normal development and cancer, and increase epigenetic plasticity and tumor cell survival. See Feinberg et al, Nature Rev Genet 2016, 17:284.

  Can epigenetic alterations in cancer be reversed using novel approaches targeted to large blocks of heterochromatin and/or metabolism? See: McDonald et al, Nature Genet 2017, 49:367.

  What are the epigenetic drivers of neuropsychiatric disease and how are they related to brain-region specific developmental epigenetic marks? See: Rizzardi et al, Nature Neurosci, in press.

  What is the relationship between common DNA sequence variants and tissue-specific epigenetic marks in normal development and disease? See: eGTEx Project, Nature Genet 2017, 49:1664.

  How do genome and environment interact to cause disease, and how is this mediated by the epigenome? We are addressing the mechanisms through which environment influences gene function, or “GxE”, focusing on important and contemporary exposures highly relevant to human health: diet, environmental toxicants and their relationship to metabolic disorders and cancer. See: Barrington et al, Genetics 2018, 208:399.

  What is the mathematical foundation of epigenetic information? We are pursuing our novel idea that genetic variants that control phenotypic variance confer a selective advantage in evolution in an environment that changes, and that the same idea may explain phenotypic plasticity in cancer evolution, with the “hallmarks” of cancer being selected for at the expense of the host. We are developing new information theoretic tools to relate DNA methylation, chromatin structure, and gene sequence to stochastic modeling. See: Jenkinson et al, Nature Genet 2017, 49:719.

  See our website for details: http://feinberglab.jhu.edu.

  Interested candidates must have received or expect to have received the PhD or MD/PhD in 2018 or 2019, have a strong graduate school record in genetics and/or biostatistics, and have published or have accepted one or more high-quality peer reviewed publications. To apply, please upload to this website a cover letter, C.V. including bibliography, unofficial graduate school transcript, and contact information for three references, but do not have them send letters at this time. Any questions about the position or application process can be directed to Michael Graziano at graziano@jhmi.edu, but only applications submitted through this website will be considered.

  Johns Hopkins is an equal-opportunity employer.

  以上内容由知识人网咨询老师整理发布,希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于博士后申请的相关资讯,可以登录我们的官方网站

扫一扫知识人网官方微信订阅号,关注更多学术资讯、博士后招聘信息。
国外博士后、访问学者申请免费专业评估,专业顾问在线答疑解惑。

快速申请国外博士后(免费评估)


点击这里快速申请国外博士后

点击这里快速申请国外访问学者

知识人网是专职国外博士后访问学者申请的服务机构,获评“北京诚信服务示范单位”。
自2004年起,累计十余年申请经验,以大量名校申请成功案例、及全球三万余所院校导师资源为基石,提供优质的申请咨询服务。
400电话:400-060-0581,欢迎您随时来电咨询!