当前位置:知识人网 >> 国外博士后招聘 >> 正文内容

瑞典于默奥大学分子医学/分子生物学/基因组学方向博士后招聘
文章来源:知识人网整理       更新时间:2018年11月06日

  Gene regulation in obesity related liver cancer (full-time employment for two years) in Andreas Hörnblad’s research group. The focus of the research group is on gene regulation and the function of the noncoding genome in metabolic diseases and during embryonic development. We use genetic mouse models in combination with next generation sequencing techniques and high-throughput genome editing to study these questions.

  Reprogramming of regulatory sequences or restructuring of the genome that involves relocation of enhancer sequences with regulatory potential has shown to play a key role in certain types of cancer. This could be due to e. g. enhancer hijacking, via activation of dormant regulatory sequences or by formation of new topological domains. Liver cancer is the fifth most common cancer form in the world and the second leading cause of cancer-related deaths. The most common form of liver cancer, hepatocellular carcinoma, is strongly associated with obesity and metabolic syndrome. The disease aetiology of liver cancer is complicated and it is not clear how specific genes contribute to different forms of cancer — e.g. against the background of metabolic syndrome or obesity. In addition, little is known about how mutations in the non-coding regulatory genome contribute to the disease.

  The group is based at the Umeå Center for Molecular Medicine at Umeå University campus. At the department, strong research is conducted in the fields of metabolism, imaging, neuroscience and cancer. The centre provides all necessary instrumentation and a number of different model organisms are represented. In the laboratory there is a strong background on the redundancy and modularity of regulatory elements (enhancers) as well as the study of metabolic diseases, developmental biology and mouse genetics. We are looking for a motivated post-doctor to study the role of the non-coding genome in the development of liver cancer in metabolic syndrome and obesity.

  Duties

  Experimental methodology includes various forms of next generation sequencing (RNA-seq, ChIP-seq, ATAC-seq etc) to study genomic sequences and epigenetic markers (activity of enhancers, promoters, etc.) in tumors from mouse models, human patients as well as in human cell lines. The work also includes metabolic analyses in vivo, genetic engineering of mice and cell lines (CRISPR/Cas9), gene and protein expression analyses, advanced in vivo imaging and microscopy. The successful candidate must be able to independently plan experiments, develop methods and conduct data analysis as well as communicate results. Summarising results orally and in writing in English is a requirement, as well as documented good ability to collaborate within the group and with other research groups. The position is fully covered for 2 years but the candidate will also be encouraged to apply for her/his own grants. We are looking for a curious and driven researcher with independent and critical thinking, who will be given the opportunity to develop her/his scientific knowledge.

  The successful candidate will be responsible for:

  - Conduct research within the framework of the group’s research program

  - Establish methods

  - Analyse and publish research results

  - Project leading

  - Actively participate in journal clubs, seminars, tutoring of students etc.

  - Present data at national and international scientific meetings

  Qualifications

  A doctoral degree in the field of molecular medicine or related disciplines is required as well as a strong background in molecular biology or genomics. Experience with ChIP-, RNA- or ATAC-sequencing and/or CRISPR/Cas9 technology are desirable skills. Training in experimental animal science as well as documented experience in independently managing laboratory animals are desirable but not a requirement. Publications in the areas of metabolic syndrome, liver cancer or gene regulation is a merit. Basic knowledge in bioinformatics is an advantage and opportunities for further education will be given. As a post-doctor, the candidate must be able to conduct independent research work and be able to write scientific reports and publications. Knowledge of written and spoken English is a requirement.

  Applicants may be contacted for an interview before the end of the application period, but decisions to proceed in the recruitment process will be taken only after the application period has expired.

  以上内容由知识人网咨询老师整理发布,希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于国外博士后招聘的相关资讯,可以登录我们的官方网站。

扫一扫知识人网官方微信订阅号,关注更多学术资讯、博士后招聘信息。
国外博士后、访问学者申请免费专业评估,专业顾问在线答疑解惑。

快速申请国外博士后(免费评估)


点击这里快速申请国外博士后

点击这里快速申请国外访问学者

知识人网是专职国外博士后访问学者申请的服务机构,获评“北京诚信服务示范单位”。
自2004年起,累计十余年申请经验,以大量名校申请成功案例、及全球三万余所院校导师资源为基石,提供优质的申请咨询服务。
400电话:400-060-0581,欢迎您随时来电咨询!