美国纽约大学医学院系统基因博士后职位

　　What we offer

　　Two Postdoctoral positions are available for a wet-lab project, a dry-lab project or a combination of both. Applicants with a background in genetics/molecular biology and/or bioinformatics are encouraged to apply. The Postdoctoral Researcher will have the opportunity to receive training on the use of state-of-the-art cancer genetics approaches and genomics analyses of patients’ datasets. The projects may require working with mice, including mouse models of human tumors, which will enable testing hypotheses that result from in vitro experiments. The Postdoctoral Researcher will be fully engaged with the intellectual activities in the lab and be responsible for organizing, processing, and reporting data.

　　Research Project

　　We are looking for highly motivated scientists with great communication skills and collaborative spirit and love for science. The projects will mainly focus on cancer genetics and aneuploidy as described below.

　　The maintenance of a normal complement of the genome is a requirement for the success of multicellular organisms. Aneuploidy refers to the presence of an abnormal (lower or higher than euploid) number of chromosomes and is extremely frequent (~90%) in human tumors (Beroukhim et al., 2010). Despite the fact that aneuploidy is so frequent in cancer, little is known about whether and how aneuploidy contributes to tumorigenesis and how aneuploidy could be targeted for cancer therapy.

　　We recently conducted a combined analysis of point mutation and copy number data in primary human tumor samples and demonstrated that the distribution and potency of cancer driver genes on each chromosome or chromosome arm can predict the frequency of whole chromosome or chromosome arm aneuploidy across cancers (Davoli et al., 2013). This suggests that the recurrent patterns of aneuploidy in cancer act as driver events during tumorigenesis. More recently, we expanded the analysis on datasets from primary human tumors and have identified an interesting relationship between the level of cancer aneuploidy and the extent of tumor immune infiltrate (Davoli et al., 2017). Our ongoing research interest is to determine whether and how cancer aneuploidy regulates different aspects of cancer development utilizing a combination of experimental and computational approaches.

　　https://www.davolilab.com/

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