Postdoc and PhD Position On The Microenvironmental Control Of Hallmarks of Cancer : Giessen, Germany

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for

1 POSTDOC AND 1 PHD POSITION:
MICROENVIRONMENTAL CONTROL OF HALLMARKS OF CANCER

in the field of tumor biology / neurooncology. The positions are available immediately.

Your profile:

Postdoc:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong track record and research background in molecular and cell biology. Experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: hypoxic signalling, functional genomics or other high-throughput screening methods, epigenetics or in vivotumor (brain) metastasis models, advanced microscopy methods, analysis of signalling pathways, proteomic analysis including analysis of posttranslational modifications, protein biochemistry.

PhD student:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain an MSc degree, diploma or equivalent. The applicants should possess a strong interest in cancer research, molecular and cell biology, the ability to integrate in an international team, learn about new fields and establish new experimental techniques. Prior experience with laboratory mouse, cell culture, or tumor biology related assays will be an advantage.

Topic:

Regions of low oxygen tension are common findings in malignant tumors, being associated with increased frequency of tumor invasion and metastasis, and thus critically determining the clinical behaviour and outcome of tumors. We work on a broad range of topics, primarily related to the functions of the members of the oxygen sensing pathway – HIFs, PHDs, their regulators and downstream effectors – in diverse aspects of cancer biology. We are particularly interested in understanding how stress signals from the tumor microenvironment are sensed and integrated in order to promote tumor growth and progression.The proposed projects will aim to1) dissect the role of the tumor microenvironment in brain metastasis with emphasis on the crosstalk of the oxygen sensing pathway with other cellular signalling pathways, including growth factor/RTK and metabolic signalling and 2) understand the role of 2-oxoglutarate-dependent dioxygenases and their interplay with the hypoxic tumor microenvironmentinthe epigenetic control of tumor growth and metastasis .

What we offer:

Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities including the PhD graduate program of the International Giessen Graduate school for Life Sciences (GGL http://www.uni-giessen.de/cms/fbz/zentren/ggl). We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situhybridization, light, epifluorescence and confocal microscopy, image analysis, miRNA analyses, DNA methylation array analysis, chromatin immunoprecipitation, bioinformatic analysis, animal models and in vivotumor models as well as tumor biopsies.

Application:

Please send your application as a single PDF: cover letter, your CV, certificates of your qualifications, your publication list, recommendation letters from at least two referees and their contact details until 30.09.2018 to Dr. Attila Németh (Attila.Nemeth at patho.med.uni-giessen.de)

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