Postdoctoral Positions in the Genomics of Neuropsychiatric Disorders : New York, NY, United States

The translational neurogenomics Lab at the Icahn School of Medicine at Mount Sinai is looking for two post-doctoral researchers with expertise in computational biology to lead NIMH-funded projects related to better understanding the mechanisms underlying neuropsychiatric diseases such as autism, epilepsy and schizophrenia.

One postdoctoral position is available to work on a project related to CNV/SNV/indel discovery using exome and/or whole-genome sequencing data (WGS) generated in our Lab as part of our clinical genomics program (https://pintolab.mssm.edu/nddprogram.html), and further integrate with external data. Relevant findings will be followed-up in IPSC-derived neural progenitor cells. The position requires a quantitative background and/or extensive experience with genomic data analysis. Experience in molecular biology and functional validation of disease-associated variants, including cell culture, is a plus but not required. The selected applicant will work within a multidisciplinary team, and interact with clinical scientists, clinical research coordinators and database manager. Prior experience with whole-genome/whole-exome data analysis is preferred.

The second postdoctoral position is available to work on a project related to the generation and analysis of short-read RNA-Seq and long-read sequencing (e.g PacBio Iso-Seq) in human brain samples. The position involves integrating non-coding and coding RNA from large scale data with prior genetic knowledge and epigenetic data, as well as quantifying isoforms, co-expression and network-based analyses and modeling to assess the role of non-coding RNA in gene regulatory networks. The selected applicant will work within a multidisciplinary team and participate in the PsychENCODE consortium (http://psychencode.org/). Prior experience with RNA sequencing data analysis is preferred.

We seek motivated postdoctoral candidates with strong computational and analytical skills and an interest in applying computational and systems biology approaches. The ideal candidates will have a Ph.D. in genomics, statistical genetics, computational biology, or bioinformatics with a strong background in RNA biology, and excellent quantitative skills. Both positions require demonstrated experience with UNIX, R, Python or C/C++, and expertise in statistical interpretation and analysis of genome and/or RNA-Seq data.

Specific qualifications include experience in one or more of the following areas:

• Develop and maintain genetic, genomic, and biological databases to annotate and interpret human genome data
• Analyze genomic variation using gatk pipelines, and calling genomic variants (SNVs, CNVs/indels) from exome/genome sequencing data in trio/family data
• Mapping RNAs using short and long-read (Iso-Seq) RNA sequencing data
• Annotation and reconstruction of transcript isoforms
• Co-expression and network-based/modeling
• Familiarity with large-scale GWAS

Additional qualifications include:

• Programming (e.g. python) and statistical analysis (e.g. R)
• Ability to work independently and complete tasks efficiently
• Strong work ethic and attention to detail
• Excellent communication skills with a focus on teamwork and creating usable and accessible research software tools

We offer access to superb high-performance computing. For a listing of postdoc resources at Mt Sinai, including subsidized housing, consult our selection at https://pintolab.mssm.edu/contact.html. The Icahn School of Medicine at Mount Sinai is an equal opportunity/affirmative action employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds.

To apply, please e-mail a CV, a brief description of research experience and interests, and contact information for 2-3 references to dalila.pinto@mssm.edu.
Departments of Psychiatry, and Genetics and Genomic Sciences
Mindich Child Health & Development Institute and
Icahn Institute for Genomics and Multiscale Biology
The Friedman Brain Institute
Icahn School of Medicine at Mount Sinai (Manhattan, New York)…