美国麻省剑桥计算基因组学与预测毒理学博士后职位

Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science’s promise by bringing safe, effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people’s lives.

Dr. Luke Ward and Dr. Paul Nioi are seeking a postdoctoral fellow to join the Translational Systems Biology laboratory in the Comparative Biology and Safety Sciences department at Amgen’s Cambridge campus. Our group is developing a cutting edge research program applying human genetics and stem cell models to discover and characterize drug targets and patient responses. We are seeking a postdoc with a passion for applying human genetics and predictive modeling to drug development and translational medicine. The successful applicant will be responsible for projects investigating the relationship between information about drug targets and off-targets, including knowledge from genetics and genomics, and side effects. We plan to publish the results of this work, to use these findings to guide our lab’s experimental efforts, and to ultimately transform the way we use human genetic information in preclinical research. The postdoc will interact with a diverse community of computational biologists, molecular biologists, and clinical researchers at Amgen, as well as collaborators in the Cambridge biotech and academic community.

The Amgen postdoctoral program is committed to providing scientists with an enriching environment to inspire innovation that will contribute to the development of human therapeutics. Postdocs engage in seminar programs; contribute to internal Amgen meetings including lab, team, and project meetings; participate in functional-area technical reviews; and attend external scientific conferences as well as an annual postdoctoral conference with the postdoctoral committee and senior leadership. At Amgen we offer competitive base pay and bonus opportunities. Amgen postdoctoral mentors will help you develop a strong network within the organization and with academic collaborators; facilitate timely publication of your research; and expose you to other organizations within Amgen in order for you to gain industry experience.

Most importantly, we take seriously our role as mentors to provide scientific training while nurturing your skills so that you smoothly transition into a role as an independent scientific investigator.

Basic Qualifications
Doctoral degree (Ph.D., Sc.D., or M.D.) at the time of appointment.

Preferred Qualifications
Research experience in computational biology, bioinformatics, or medical informatics is preferred. However, molecular biologists and other experimental scientists will be considered if they demonstrate a commitment to undertaking a computational research experience and a passion for human genetics
Track record of publishing original research
Ability to thrive in a highly interactive and vibrant environment designed to promote frequent interaction and brainstorming
Proficiency with a Unix computing environment, a scripting language (Perl/Python), and statistical software (R/MATLAB)
Understanding of the principles of human population genetics and clinical genetics
Familiarity with the drug development process
Familiarity with issues in medical informatics (ontologies, EMRs)
Ability to derive insights by systematic analysis of genetics, bioinformatics, pharmacology, or chemoinformatics databases
Excellent communication skills and the ability to influence and inspire