Post-doctoral Scientist Positions in NMR/Structural Biology : Hannover, Germany

Research

The successful candidates will work in the group of Prof Teresa Carlomagno (NMR-based Structural Chemistry). The group combines a wide range of structural biology techniques — including solution- and solid-state NMR, X-ray crystallography, EPR, small-angle scattering and mass-spectrometry — to investigate the structures of large and dynamic biomolecular complexes, with particular emphasis on the RNA–protein complexes involved in RNA metabolism and enzymatically active protein–protein complexes.

We are seeking three talented post-doctoral scientists to work on research projects that include:

• Investigation of the structure and activity of protein complexes involved in the regulation of gene expression.
• Structural characterization of the enzyme complexes that synthesize bioactive natural products in micro-organisms (non-ribosomal peptide synthetases).
• Development of novel solid-state NMR methods to study RNA–protein complexes and their application to the specific complexes that catalyze chemical modifications of ribosomal RNA.

The post-doctoral scientists will be involved in all stages of research, including sample preparation, biophysical characterization of in vitro-assembled complexes (for example by ITC, analytical ultracentrifugation and light-scattering techniques), development and application of NMR experiments, structure determination and computational modelling.