英国利物浦大学微生物遗传学方向博士后职位招聘

The University of Liverpool

Faculty of Health and Life Sciences

Institute of Infection and Global Health

Department of Clinical Infection, Microbiology and Immunology

Postdoctoral Research Associate in Microbial Genetics Grade 7

£32,958 pa

Based at the Ronald Ross building and working in partnership with research collaborators in Liverpool, the Wellcome Trust Sanger Institute, Malawi and Australia, you will investigate the genetic determinants of niche adaptation in the human bacterial pathogen, Streptococcus pneumoniae. Whole genome sequencing will determine signatures of niche adaptation in bacterial isolates multiply-passaged through in vivo infection models mimicking clinical infection of nasopharynx, lungs and brain, respectively. Mutagenesis will reproduce key genetic changes singly or in combination and RNA-seq analysis will determine the impact of adaptive mutations on bacterial gene expression. We aim to identify mutations and gene expression patterns associated with nasopharyngeal carriage versus disease, to identify vaccine candidates and targets for therapeutic intervention. You should have a PhD in bacterial molecular biology or bacterial genetics with skills and expertise in infection modelling, pathogen handling and generation and interpretation of genomic and transcriptomic datasets. The post is available for 3 years.